ADC Systems Optimization

Balance target biology, construct design, exposure and safety across the complete ADC system.

Explore construct combinations, optimize linker and conjugation choices, compare ADC PK/PD and therapeutic-window trade-offs, and convert liabilities into specific redesign actions.

ADC systems optimization balancing target biology, construct design, exposure and safety
Compare ADC Construct ConceptsDiscuss an ADC Optimization Program

Identify which construct to advance—and what to redesign.

Design-Space Reduction

From thousands of construct combinations to a Pareto-optimal shortlist

MedMap filters chemistry-valid designs, scores system-level performance and retains Pareto-efficient constructs so teams can compare meaningful trade-offs rather than rely on a single composite score.

Raw design space

3,476

raw combinations

Chemistry-valid space

500

chemistry-valid designs

Fully scored

500

fully scored constructs

Pareto frontier

8

Pareto-optimal constructs

Recommendation

1

recommended construct with rationale

Decision dimensions: Efficacy / Synergy / Safety / Developability / Manufacturability

Design-space reduction from raw combinations to Pareto-optimal shortlist with radar diagram of construct performance

Linker & Site Optimization

Optimize payload arms, linker chemistry and conjugation sites independently

Diagram showing independent optimization of payload arms, linker chemistry and conjugation sites

Defect-to-Action Planner

Translate predicted liabilities into specific construct changes

1. Predicted liability
2. Evidence
3. Design action
4. Expected system effect
DAR heterogeneity / CMC risk
High DAR, broad distribution, manufacturability penalty
Lower DAR or adopt site-specific conjugation
Reduce heterogeneity; improve developability and exposure consistency
Linker instability
Systemic free-payload risk or early release
Increase linker stability / change spacer or chemistry
Reduce off-tumor payload exposure
Insufficient tumor release
Low payload availability despite ADC exposure
Change cleavable mechanism or release kinetics
Increase tumor payload delivery
Narrow therapeutic window
High efficacy but poor safety margin
Jointly adjust antibody, DAR, linker and payload
Improve overall therapeutic-index balance

ADC PK/PD & Safety Window

Connect construct design to tumor payload delivery and systemic safety

Circulating intact ADC

Tumor-associated and internalized ADC

Released payload

ADC CONSTRUCT-LEVEL OPTIMIZATION

ADC construct illustration showing antibody, linker, and payload

DAR & CONJUGATION

Site-specific • DAR 4

LINKER STABILITY

FAVORABLE

SYSTEMIC PAYLOAD RISK

MODERATE

RECOMMENDATION

Advance as primary construct

Retain lower-DAR backup

Construct Comparison

Compare component choices and system-level consequences together

Construct
Internalization
Linker / release
DAR
Tumor exposure
Systemic risk
Decision
ADC-01
High
Stable / responsive
4
High
Moderate
Advance
ADC-02
High
Moderate leakage
8
High
High
Redesign
ADC-03
Moderate
Stable / slow release
4
Moderate
Low
Backup

From molecular ideas to the next experimental decision

Discuss a focused project review, pilot scope or complete optimization program with MedMap.

Compare ADC Construct Concepts